The intimate relationship between gut microbiota and cancer immunotherapy. (4th May 2019)

• Record Type: Journal Article
• Authors: Elkrief, Arielle; Derosa, Lisa; Zitvogel, Laurence; Kroemer, Guido; Routy, Bertrand
• Is Part Of: Gut microbes. Volume 10:Isuse 3(2019)
• Page Start: 424
• Page End: 428
• Publication Date: 2019-05-04
• Subjects: Gut microbiota -- cancer -- oncology -- immunotherapy -- fecal transplantation -- profiling gut microbiome -- host pathogen interactions; Gastrointestinal system -- Microbiology -- Periodicals; Microbiology -- Periodicals; Intestine, Small -- Periodicals; 616.3
• DOI: 10.1080/19490976.2018.1527167
• Languages: English
• ISSNs: 1949-0984

Abstract

ABSTRACT: Immunotherapy is widely used to treat a large variety of malignancies and has revolutionized the therapeutic approach to cancer. Major efforts are ongoing to identify biomarkers that predict response to immunotherapy as well as new strategies to improve ICI efficacy and clinical outcomes. Studies have shown that the gut microbiome determines the extent to which ICIs may invigorate the anticancer immune response. Here, the authors review recent studies that have described the effects of the gut microbiota on the efficacy of CTLA-4 and PD-1 inhibitors and outline potential future clinical directions of these findings.