Beneficial effect of low dose gamma irradiation or quercetin on Cerastes cerastes snake venom induced toxicity in male rats. (2nd January 2021)

• Record Type: Journal Article
• Authors: Karam, Heba; Mohamed, Marwa
• Is Part Of: Toxin reviews. Volume 40:Number 1(2021)
• Page Start: 35
• Page End: 47
• Publication Date: 2021-01-02
• Subjects: Cerastes cerastes -- venom toxicity -- low dose irradiation -- quercetin; Toxicology -- Periodicals; Toxins -- Periodicals; 615.905
• DOI: 10.1080/15569543.2019.1580746
• Languages: English
• ISSNs: 1556-9543

Abstract

Abstract: This study aimed to evaluate the role of low dose gamma irradiation (IRR) on snake venom induced toxicity in male rats using quercetin as a reference antioxidant. Sixty rats were divided equally into six groups. Control, Venom, IRR, Quercetin, Venom + IRR, and Venom + Quercetin. Serum liver and kidney functions were ameliorated after treatments, as well as, Paroxonase and superoxide dismutase activities, nitric oxide, malondialdehyde, and tumor necrosis factor α levels in liver and kidney tissues also NF-kB gene expression in tissues. Moreover, histopathological study confirmed these improvements. Thus, low dose IRR as well as quercetin was found to be a reliable tool in the treatment of snakebites. Abstract :