Identifiability of pharmacological models for online individualization. Issue 15 (2021)

• Record Type: Journal Article
• Authors: Wahlquist, Ylva; Gojak, Amina; Soltesz, Kristian
• Is Part Of: IFAC-PapersOnLine. Volume 54:Issue 15(2021)
• Page Start: 25
• Page End: 30
• Publication Date: 2021
• Subjects: Individualized anesthesia -- Drug delivery -- Identifiability -- Pharmacokinetic/pharmacodynamic modeling -- Sensitivity analysis; Automatic control -- Periodicals; 629.805
• DOI: 10.1016/j.ifacol.2021.10.226
• Languages: English
• ISSNs: 2405-8963

Abstract

Abstract: There is a large variability between individuals in the response to anesthetic drugs, that seriously limits the achievable performance of closed-loop controlled drug dosing. Full individualization of patient models based on early clinical response data has been suggested as a means to improve performance with maintained robustness (safety). We use estimation theoretic analysis and realization theory to characterize practical identifiability of the standard pharmacological model structure from anesthetic induction phase data and conclude that such approaches are not practically feasible.