Radiofrequency and microwave ablation in a porcine liver model: non-contrast CT and ultrasound radiologic-pathologic correlation. (1st January 2020)

• Record Type: Journal Article
• Authors: Ziemlewicz, Timothy J.; Hinshaw, J. Louis; Lubner, Meghan G.; Knott, Emily A.; Willey, Bridgett J.; Lee, Fred T.; Brace, Christopher L.
• Is Part Of: International journal of hyperthermia. Volume 37:Number 1(2020)
• Page Start: 799
• Page End: 807
• Publication Date: 2020-01-01
• Subjects: Thermal ablation -- radiologic pathologic correlation -- radiofrequency -- microwave -- hepatic ablation; Thermotherapy -- Periodicals; 615.832
• DOI: 10.1080/02656736.2020.1784471
• Languages: English
• ISSNs: 0265-6736

Abstract

Abstract: Purpose: The goal of this study was to compare intra-procedural radiofrequency (RF) and microwave ablation appearance on non-contrast CT (NCCT) and ultrasound to the zone of pathologic necrosis. Materials and methods: Twenty-one 5-min ablations were performed in vivo in swine liver with (1) microwave at 140 W, (2) microwave at 70 W, or (3) RF at 200 W ( n = 7 each). CT and US images were obtained simultaneously at 1, 3, and 5 min during ablation and 2, 5, and 10 min post-ablation. Each ablation was sectioned in the plane of the ultrasound image and underwent vital staining to delineate cellular necrosis. CT was reformatted to the same plane as the ultrasound transducer and transverse diameters of gas and hypoechoic/hypoattenuating zones at each time point were measured. CT, ultrasound and gross pathologic diameter measurements were compared using Student's t -tests and linear regression. Results: Visible gas and the hypoechoic zone on US images were more predictive of the pathologic ablation zone than on NCCT images ( p < 0.05). The zone of necrosis was larger than the zone of visible gas on US (mean 3.2 mm for microwave, 6.4 mm for RF) and NCCT (7.6 mm microwave, 13.9 mm RF) images ( p < 0.05). The zone of visible gas and hypoechoic zone on US are more predictive of pathology with microwave ablations when compared with RF ablations ( p < 0.05). Conclusion: When evaluating images during energy delivery, US is more accurate than CT and microwave- more predictable than RF-ablation based on correlation with in-plane pathology.