Studies on antimicrobial peptide-loaded nanomaterial for root caries restorations to inhibit periodontitis related pathogens in periodontitis care. (17th February 2021)

• Record Type: Journal Article
• Authors: Hu, Yuqian; Chen, Yan; Lin, Lijuan; Zhang, Jinhui; Lan, Rengang; Wu, Buling
• Is Part Of: Journal of microencapsulation. Volume 38:Number 2(2021)
• Page Start: 89
• Page End: 99
• Publication Date: 2021-02-17
• Subjects: Nal-P-113 -- drug conjugates -- nanosuspension -- drug delivery -- periodontitis -- biofilm; Microencapsulation -- Periodicals; Controlled release technology -- Periodicals; 615.19
• DOI: 10.1080/02652048.2020.1842528
• Languages: English
• ISSNs: 0265-2048

Abstract

Abstract: Aims: To prepare a novel antimicrobial peptide Nal-P-113 loaded poly (ethylene glycol) combined chitosan nanoparticles (Nal-P-113-PEG-CSNPs) for root caries restorations to control the periodontitis related pathogens in periodontitis care. Methods: Nanoparticles were prepared by simple polymerisation method and characterised using effective analytical methods (TEM, UV, etc.). The antimicrobial activity and biofilm formation of Nal-P-113-PEG-CSNPs was tested against periodontal bacterial pathogens by different in vitro methods. Results: The size of Nal-P-113 loaded PEG-Chitosn nanoparticles was 216.2 ± 1.6 nm. The drug encapsulation efficiency (%EE (w/w) of Nal-P-113-PEG-CSNPs was found to be 89.33 ± 1.67% (w/w). The antimicrobial examination showed that prepared NPs have effectively inhibited the growth of Fusobacterium nucleatum, Streptococcus gordonii, and Porphyromonas gingivalis with the MIC of 23 µg/mL, 6 µg/mL and 31 µg/mL, respectively. Conclusions: The prepared antimicrobial peptide-loaded PEG-CSNPs provide excellent in vitro efficiency but, further studies are necessary to confirm its therapeutic efficacy on periodontitis care.