Dual role of PRMT1-dependent arginine methylation in cellular responses to genotoxic stress. (3rd July 2020)

• Record Type: Journal Article
• Authors: Giambruno, Roberto; Bonaldi, Tiziana
• Is Part Of: Molecular & cellular oncology. Volume 7:Number 4(2020)
• Publication Date: 2020-07-03
• Subjects: Arginine methylation -- mass spectrometry-based proteomics -- PRMT1 -- SASP -- cisplatin -- stress granules -- LLPS -- phosphorylation; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2020.1743808
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: We have recently shown that arginine methylation by protein arginine N-methyltransferase 1 (PRMT1) controls the response to cisplatin in ovarian cancer cells. In addition to increased methylation of chromatin proteins that favors senescence-associated secretory phenotype (SASP) activation, our study unraveled global hypo-methylation of RNA-binding proteins, which – we speculate – may promote their phase separation and stress granules formation.