Paraneoplastic Neurologic Symptoms in a Pediatric Patient with Hodgkin Lymphoma. (7th February 2021)

• Record Type: Journal Article
• Authors: Baniel, Claire C.; Donaldson, Sarah S.; Aftandilian, Catherine; Hiniker, Susan M.
• Is Part Of: Cancer investigation. Volume 39:Number 2(2021)
• Page Start: 159
• Page End: 162
• Publication Date: 2021-02-07
• Subjects: Paraneoplastic syndrome -- achalasia -- Hodgkin lymphoma -- pediatric cancers; Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.1080/07357907.2020.1852412
• Languages: English
• ISSNs: 0735-7907

Abstract

Abstract: Neurological paraneoplastic syndromes are exceedingly rare, and often difficult to recognize clinically. Paraneoplastic achalasia is a condition characterized by new-onset dysphagia that is unrelated to tumor burden, most often due to the development of auto-immune antibodies targeting esophageal tissue. Due to the rarity of this condition, diagnosis is often delayed, leading to increased time to treatment. Here we report a case of a rare paraneoplastic achalasia in a female child with EBV + Hodgkin lymphoma (HL), review literature describing paraneoplastic achalasia, and discuss treatment strategies for improving clinical outcome in these patients.