Hippobutenolides A and B, two new long-chain fatty acid esters from the marine sponge Hippospongia lachne. (9th November 2021)

• Record Type: Journal Article
• Authors: Hong, Li-Li; Wang, Jie; Liu, Li-Yun; Sun, Fan; Sun, Jia-Bao; Miao, Xian-Xian; Liu, Hong-Yan; Zhan, Kai-Xuan; Jiao, Wei-Hua; Lin, Hou-Wen
• Is Part Of: Tetrahedron letters. Volume 84(2021)
• Publication Date: 2021-11-09
• Subjects: Hippospongia lachne -- Marine sponge -- Fatty acid ester -- Natural product; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2021.153437
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: Two new fatty acid esters, hippobutenolides A (1 ) and B (2 ), featuring a long linear aliphatic chain attached to a butanolide residue, together with two known related ones (3 and 4 ), were isolated from the marine sponge Hippospongia lachne . The structures of all compounds were determined by extensive spectroscopic analysis and modified Mosher's method. All isolates were evaluated for cytotoxicity against three non-small cell lung cancer (NSCLC) cells (A549, PC9, and HCC827) as well as one cisplatin-resistant NSCLC cell (A549-DDP) and two gefitinib-resistant NSCLC cells (PC9-GR and HCC827-GR). Compound 3 displayed cytotoxicity against all cell lines with IC50 values ranging from 18.86 to 33.24 μM.