Optical Coherence Tomography Angiography Findings in Active and Inactive Ocular Behçet Disease. (18th May 2020)

• Record Type: Journal Article
• Authors: Accorinti, Massimo; Gilardi, Marta; De Geronimo, Daniele; Iannetti, Ludovico; Giannini, Daniela; Parravano, Mariacristina
• Is Part Of: Ocular immunology and inflammation. Volume 28:Number 4(2020)
• Page Start: 589
• Page End: 600
• Publication Date: 2020-05-18
• Subjects: Behçet disease -- fluorescein angiography -- OCT angiography -- uveitis -- vessel density; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.1080/09273948.2019.1612452
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: Purpose: To study macular microvascular changes in ocular Behçet disease (OBD) using optical coherence tomography angiography (OCTA). Methods: Quantitative and qualitative analyses of OCTA were performed on 23 OBD patients with active or inactive uveitis and compared with healthy controls. Results: Deep capillary plexus (DCP) is the most frequently involved in OBD (p < 0.001). Its vessel density (VD) is reduced compared with controls in both active (p < 0.007) and inactive uveitis (p = 0.03). In inactive uveitis, VD is inversely related to the number of uveitis relapses (superficial capillary plexus: r = –0.694, p = 0.004; DCP: r = –0.541, p = 0.037) and it is significantly reduced in patients with a uveitis-free period ≥5 years compared with healthy controls (p < 0.038). Conclusions: Macular VD is reduced in Behçet patients with active and inactive uveitis, especially in DCP. In inactive uveitis, VD is inversely related to the number of ocular relapses and cannot be restored during time.