Ten-eleven translocation proteins and their role beyond DNA demethylation – what we can learn from the fly. Issue 11 (1st November 2020)

• Record Type: Journal Article
• Authors: Ismail, Joy N.; Ghannam, Mirna; Al Outa, Amani; Frey, Felice; Shirinian, Margret
• Is Part Of: Epigenetics. Volume 15:Issue 11(2020)
• Page Start: 1139
• Page End: 1150
• Publication Date: 2020-11-01
• Subjects: Drosophila -- epigenetics -- DNA demethylation -- neuroscience -- cancer biology; Epigenesis -- Periodicals; Epigenetica; 572.86505
• DOI: 10.1080/15592294.2020.1767323
• Languages: English
• ISSNs: 1559-2294

Abstract

ABSTRACT: Ten-eleven Translocation (TET) proteins have emerged as a family of epigenetic regulators that are important during development and have been implicated in various types of cancers. TET is a highly conserved protein that has orthologues in almost all multicellular organisms. Here, we review recent literature on the novel substrate specificity of this family of DNA 5-methylcytosine demethylases on DNA 6-methyladenine and RNA 5-methylcytosine that were first identified in the invertebrate model Drosophila . We focus on the biological role of these novel epigenetic marks in the fruit fly and mammals and highlight TET proteins' critical function during development specifically in brain development.