High-risk human papillomavirus positive primary squamous cell carcinoma of the lacrimal gland: a case report. (2nd January 2021)

• Record Type: Journal Article
• Authors: Zhao, Jiawei; Quon, Harry; Koch, Wayne; Rooper, Lisa M; Campbell, Ashley A
• Is Part Of: Orbit. Volume 40:Number 1(2021)
• Page Start: 65
• Page End: 68
• Publication Date: 2021-01-02
• Subjects: High risk human papillomavirus -- lacrimal gland -- squamous cell carcinoma; Eye-sockets -- Surgery -- Periodicals; Eye-sockets -- Diseases -- Periodicals; Orbit -- surgery -- Periodicals; Orbital Diseases -- Periodicals; 617.7
• DOI: 10.1080/01676830.2020.1718714
• Languages: English
• ISSNs: 0167-6830

Abstract

ABSTRACT: A 78-year-old Caucasian female presented with a painless mass in the right orbit that had progressively enlarged over several months. Computed tomography scan of the orbits showed a right lacrimal gland mass with no bony erosion. Histopathologic analysis of the biopsy specimen revealed invasive squamous cell carcinoma positive via in-situ hybridization for high-risk human papillomavirus. The patient underwent successful removal of the right lacrimal gland tumor en bloc, followed by adjuvant radiotherapy. This is an extremely rare case of primary squamous cell carcinoma of the lacrimal gland and the first report describing human papillomavirus positivity in this tumor location.