A Wide Spectrum of Ocular Manifestations Signify Patients with Systemic Sclerosis. (2nd January 2021)

• Record Type: Journal Article
• Authors: Szucs, Gabriella; Szekanecz, Zoltan; Aszalos, Zsuzsa; Gesztelyi, Rudolf; Zsuga, Judit; Szodoray, Peter; Kemeny-Beke, Adam
• Is Part Of: Ocular immunology and inflammation. Volume 29:Number 1(2021)
• Page Start: 81
• Page End: 89
• Publication Date: 2021-01-02
• Subjects: Dry eye disease -- nailfold capillaroscopy -- ocular findings -- ocular manifestations -- pathogenesis -- scleroderma -- systemic sclerosis; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.1080/09273948.2019.1657467
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: Objectives : Systemic sclerosis (SSc) is a rare, chronic connective tissue disease involving multiple organ systems, including the eye. We evaluated the detailed clinical ocular manifestations of outpatients with SSc. Methods : Demographics, disease duration and subtype, nailfold capillaroscopy (NFC) patterns and laboratory parameters encompassing the autoantibody profile of 51 SSc patients were evaluated, and a general ocular examination was performed for each participant. Results : Twenty-nine patients (56.86%) had eyelid skin alterations, 26 (50.98%) had retinal abnormalities, 26 (50.98%) had cataracts, 8 (15.69%) had conjunctival changes, 7 (13.73%) had iris abnormalities, 33 (64.71%) suffered from dry eye disease (DED), and 11 (21.57%) suffered from glaucoma. Significant positive correlations were found between NFC data and both tear breakup time and Ocular Surface Disease Index test values. Conclusions : Eyelid skin abnormalities, DED and retinal abnormalities are among the most common SSc-related ocular involvements. Diverse ophthalmic findings are attributed to the heterogeneity of SSc.