Circulating follicular helper T cells and subsets are associated with immune response to hepatitis B vaccination. Issue 2 (1st February 2021)

• Record Type: Journal Article
• Authors: Yin, Mingjuan; Xiong, Yongzhen; Huang, Lingfeng; Liu, Gang; Yu, Zuwei; Zhao, Yi; Zhao, Jie; Zhang, Yan; Lian, Tingyu; Huang, Jingxiao; Liang, DongMei; Zeng, JinMei; Ni, Jindong
• Is Part Of: Human vaccines & immunotherapeutics. Volume 17:Issue 2(2021)
• Page Start: 566
• Page End: 574
• Publication Date: 2021-02-01
• Subjects: Circulating follicular helper T cells -- immune response -- hepatitis B vaccination; Vaccines -- Periodicals; 615.372
• DOI: 10.1080/21645515.2020.1775457
• Languages: English
• ISSNs: 2164-5515

Abstract

ABSTRACT: Around 5–10% of healthy vaccinees lack or produce an inadequate antibody response following receipt of a standard hepatitis B vaccination regimen. Studying immune response to hepatitis B vaccination could promote researches of immunological events contributing to this poor response. To address this, we investigated follicular helper T (Tfh) cells and firstly demonstrated similar kinetics between circulating Tfh (cTfh) cells and Tfh cells derived from mice spleen after hepatitis B vaccination. And cTfh cells were positively associated with anti-HBs at one week after vaccination (D7). Furthermore, we found PBMCs stimulated by HBsAg showed preferential activation of CXCR3 − Tfh cells subsets in vitro . The expression of transcription factor BCL6 in CD4 + T cell significantly differed between D7 and four weeks after vaccination (D28). However, dynamic curve of CD19 + B cells tended to rise then fall but no significant trends were observed. Our findings revealed a decrease in cTfh cells and subset skewing contribute to reduced antibody responses in immune response to hepatitis B vaccination, which indicated the importance of Tfh cell in facilitating the optimization of vaccine efficacy.