Association of Apolipoprotein E gene polymorphism with Preeclampsia: a meta-analysis. (2nd April 2020)

• Record Type: Journal Article
• Authors: Abyadeh, Morteza; Heydarinejad, Fatemeh; Khakpash, Maliheh; Asefi, Yaser; Shab-Bidar, Sakineh
• Is Part Of: Hypertension in pregnancy. Volume 39:Number 2(2020)
• Page Start: 196
• Page End: 202
• Publication Date: 2020-04-02
• Subjects: Apolipoprotein E -- polymorphism -- preeclampsia -- meta-analysis; Hypertension in pregnancy -- Periodicals; Pregnancy -- Complications -- Periodicals; 618.3261
• DOI: 10.1080/10641955.2020.1753068
• Languages: English
• ISSNs: 1064-1955

Abstract

ABSTRACT: Objective: The aim of this meta-analysis was to examine the association of ApoE polymorphism with the risk of developing PE. Methods: A comprehensive search was carried out through PubMed, Scopus, and Embase. The ORs with corresponding 95% CIs were extracted. Fixed model was used for meta-analysis and in case of existing heterogeneity a random-effects model was applied. Results: Association of ApoE polymorphism with the risk of developing PE was not statistically significant (OR = 0.86, 95% CI: 0.67–1.11; OR = 0.92, 95%CI: 0.73–1.15, respectively for ε2 and ε4). Conclusion: ApoE polymorphism might not be associated with the risk of PE.