Correlation between CH2DS2-VASc Score and Serum Leptin Levels in Cardioembolic Stroke Patients: The Impact of Metabolic Syndrome. (31st October 2017)

• Record Type: Journal Article
• Authors: Szczepańska-Szerej, Anna; Kurzepa, Jacek; Grabarska, Aneta; Bielewicz, Joanna; Wlizło-Dyś, Ewa; Rejdak, Konrad
• Other Names: Acuña-Castroviejo Darío Academic Editor.
• Is Part Of: International journal of endocrinology. Volume 2017(2017)
• Publication Date: 2017-10-31
• Subjects: Endocrinology -- Periodicals; Endocrinology; Endocrinology -- Periodicals; Endocrine System Diseases -- Periodicals; Periodicals; 616.4
• DOI: 10.1155/2017/7503763
• Languages: English
• ISSNs: 1687-8337

Abstract

Abstract : Objective . To determine adipokines levels in patients with different etiologic subtypes of acute ischemic stroke (AIS) and metabolic syndrome (MetS) status. Methods . Serum adiponectin, leptin, and resistin levels were determined by ELISA in 99 AIS patients and 59 stroke-free control group subjects. Stroke patients were grouped based on MetS, modified TOAST classification, and CHA2 DS2 -VASc scale in case of cardioembolic stroke following atrial fibrillation. Results . No differences were found in all adipokine serum levels between AIS patients and appropriately matched control group. MetS-AIS patients had significantly higher leptin levels (22.71 ± 19.01 ng/ml versus 8.95 ± 9.22 ng/ml, p < 0.001 ) and lower adiponectin levels (10.71 ± 8.59 ng/ml versus 14.93 ± 10.95 ng/ml, p < 0.05 ) than non-MetS-AIS patients. In patients with cardioembolic stroke, leptin levels were significantly higher than in remaining stroke cases (19.57 ± 20.53 ng/ml versus 13.17 ± 12.36 ng/ml, p < 0.05 ) and CHA2 DS2 -VASc score positively correlated with leptin levels only (p < 0.001 ). Analysis of individual components of CHA2 DS2 -VASc score showed that hypertension, female gender, and diabetes had greatest impact on elevated serum leptin level. Conclusion . This pilot study revealed that leptin could be a potential biomarker for risk stratification of cardioembolic stroke in MetS patients and that heterogeneity of stroke subtypes should be considered for more refined and precise clinical stroke studies.