Protein translocation into the ERGIC: an upstream event of secretory autophagy. Issue 7 (2nd July 2020)

• Record Type: Journal Article
• Authors: Liu, Lei; Zhang, Min; Ge, Liang
• Is Part Of: Autophagy. Volume 16:Issue 7(2020)
• Page Start: 1358
• Page End: 1360
• Publication Date: 2020-07-02
• Subjects: Autophagy -- ERGIC -- HSP90 -- membrane trafficking -- protein translocation -- TMED10 -- unconventional protein secretion; Autophagic vacuoles -- Periodicals; Apoptosis -- Periodicals; Cell death -- Periodicals; Lysosomes -- Periodicals; Degeneration (Pathology) -- Periodicals; Autophagy -- Periodicals; Cell Death -- Periodicals; Lysosomes -- Periodicals; Periodicals; 571.936
• DOI: 10.1080/15548627.2020.1768668
• Languages: English
• ISSNs: 1554-8627

Abstract

ABSTRACT: Macroautophagy/autophagy was recently shown to regulate unconventional protein secretion through a process called secretory autophagy. How the secretory cargo selectively enters into the secretory autophagosome has been a central question. Our recent studies indicate that cargo translocation into the ER-Golgi intermediate compartment, a compartment contributing membranes to the forming autophagosome, acts as a mechanism for secretory cargo entry into the vesicle and may be an early step for secretory autophagy.