OGT as potential novel target: Structure, function and inhibitors. (25th April 2022)

• Record Type: Journal Article
• Authors: Zhang, Ning; Jiang, Hongli; Zhang, Kexin; Zhu, Jiaxin; Wang, Zhongzhong; Long, Yiteng; He, Yanjun; Feng, Feng; Liu, Wenyuan; Ye, Feng; Qu, Wei
• Is Part Of: Chemico-biological interactions. Volume 357(2022)
• Publication Date: 2022-04-25
• Subjects: O-Linked N-acetylglucosamine transferase -- O-GlcNAcylation -- OGT inhibitors; Biochemistry -- Periodicals; Toxicological chemistry -- Periodicals; Biochemistry -- Periodicals; Biologie moléculaire -- Périodiques; Biochimie -- Périodiques; Toxicologie biochimique -- Périodiques; 572
• DOI: 10.1016/j.cbi.2022.109886
• Languages: English
• ISSNs: 0009-2797

Abstract

Abstract: O-linked N-acetylglucosamine transferase (OGT), a key protein in O-linked N-acetylglucosamine (O-GlcNAc) post-translational modification, catalyzes O-GlcNAcylation by linking GlcNAc from glycosyl donors to protein Ser/Thr residues to regulate multiple biological processes. OGT has become a popular research topic in the field of glycobiology as a potential target. This report consists of three parts, namely: the basic information of OGT, the relationship between OGT and diseases, and the research progress of OGT inhibitors. This report aims to improve the understanding of OGT-related fields from the perspective of its structure. OGT inhibitors could aid the effective and efficient investigation of the O-GlcNAcylation mechanism, and provide new ideas and methods for the treatment of related diseases. Highlights: Structure and function of OGT protein. Relationship between OGT protein and diseases. A comprehensive summary of the reported OGT inhibitors. Design ideas and directions of OGT inhibitors.