Association of Polymorphisms in Toll-Like Receptors 4 and 9 with Autoimmune Thyroid Disease in Korean Pediatric Patients. (20th August 2017)

• Record Type: Journal Article
• Authors: Cho, Won Kyoung; Jang, Jung-Pil; Choi, Eun-Jeong; Ahn, Moonbae; Kim, Shin Hee; Cho, Kyoung Soon; Park, So Hyun; Baek, In Cheol; Jung, Min Ho; Kim, Tai-Gyu; Suh, Byung-Kyu
• Other Names: Dufau Maria L. Academic Editor.
• Is Part Of: International journal of endocrinology. Volume 2017(2017)
• Publication Date: 2017-08-20
• Subjects: Endocrinology -- Periodicals; Endocrinology; Endocrinology -- Periodicals; Endocrine System Diseases -- Periodicals; Periodicals; 616.4
• DOI: 10.1155/2017/2304218
• Languages: English
• ISSNs: 1687-8337

Abstract

Abstract : Background . Toll-like receptors ( TLRs ) have been suggested to be associated with the development of AITD. Methods . Fifteen single-nucleotide polymorphisms in 7 TLR genes were analyzed in 104 Korean children (girls = 86, boys = 18) with AITD (Hashimoto disease (HD) = 44, Graves' disease (GD) = 60, thyroid-associated ophthalmopathy (TAO) = 29, and non-TAO = 31) with 183 controls. Results. GD showed higher frequencies of the TLR4 rs1927911 C allele than control. TAO showed a lower frequency of the TLR4 rs1927911 CT genotype and non-TAO showed a higher frequency of the TLR4 rs1927911 CC genotype than control. The frequency of the TLR9 rs187084 CC genotype in TAO was higher than that in non-TAO. GD females showed a higher frequency of the TLR 4 rs10759932 T allele, rs1927911 CC genotype, and the rs1927911 C allele than controls. GD males showed a higher frequency of the TLR4 rs10759932 CC genotype and rs1927911 TT genotype and lower frequency of the rs1927911 CT genotype than control. The frequency of the TLR4 rs10759932 CC genotype, C allele and rs1927911 TT genotype, and T allele in a GD female were lower than in a GD male. Conclusions. Our results suggest that TLR4 and 9 polymorphisms might contribute to the pathogenesis of GD and TAO.