Does MMP-9 Gene Polymorphism Play a Role in Pituitary Adenoma Development?. (17th January 2017)

• Record Type: Journal Article
• Authors: Glebauskiene, Brigita; Liutkeviciene, Rasa; Vilkeviciute, Alvita; Kriauciuniene, Loresa; Jakstiene, Silvija; Zlatkute, Egle; Tamosiunas, Abdonas; Zemaitiene, Reda; Vaitkiene, Paulina; Zaliuniene, Dalia
• Other Names: Pichler Robert Academic Editor.
• Is Part Of: Disease markers. Volume 2017(2017)
• Publication Date: 2017-01-17
• Subjects: Diagnosis -- Periodicals; Biochemical markers -- Periodicals; Pathology -- Periodicals; 616
• DOI: 10.1155/2017/5839528
• Languages: English
• ISSNs: 0278-0240

Abstract

Abstract : Purpose . To determine if the MMP-9 genotype has an influence on development of pituitary adenoma (PA). Methodology . The study enrolled n = 86 patients with PA and n = 526 healthy controls (reference group). The genotyping of MMP-9 was carried out using the real-time polymerase chain reaction method. Results . Our data demonstrated that the MMP-9 (–1562) C/C genotype was more frequent in PA group than in healthy controls (81.4% versus 64.6%, p = 0.002 ); C/C genotype was more frequently present in PA females compared to healthy control females, 81.5% versus 64.6%, p = 0.018, as well. MMP-9 (–1562) C/C genotype was frequently observed for all subgroups: noninvasive and invasive, nonrecurrence, and inactive PA compared to healthy controls: 81.8% versus 64.6%, p = 0.021 ; 81.0% versus 64.6%, p = 0.041 ; 81.8% versus 64.6%, p = 0.005 ; 100.0% versus 64.6%, p < 0.001, respectively. MMP-9 (–1562) C/C genotype was more frequent in inactive PA compared to active PA: 100.0% versus 71.4%; p < 0.001 . Conclusion . MMP-9 (–1562) C/C genotype plays a role in nonrecurrence, inactive, and invasive as well as in nonivasive PA development.