Association of ABO Blood Types and Clinicopathological Features of Prostate Cancer. (9th October 2017)

• Record Type: Journal Article
• Authors: Wang, Fang-Ming; Zhang, Yan; Zhang, Gui-Ming; Liu, Ya-Nan; Sun, Li-Jiang; Liu, Yong
• Other Names: Malaguarnera Michele Academic Editor.
• Is Part Of: Disease markers. Volume 2017(2017)
• Publication Date: 2017-10-09
• Subjects: Diagnosis -- Periodicals; Biochemical markers -- Periodicals; Pathology -- Periodicals; 616
• DOI: 10.1155/2017/9237481
• Languages: English
• ISSNs: 0278-0240

Abstract

Abstract : Purpose . To investigate the association between ABO blood types and clinicopathological characteristics in patients with prostate cancer (PC). Methods . A total of 237 pathologically diagnosed PC patients were enrolled. All patients were classified as low–middle or high-risk group. The correlation of ABO blood types with high-risk PC was determined by univariate and multivariate regression analysis. Results . Data indicated 144 (85.7%) patients were stratified as high risk in the non-O group, while 50 (72.5%) patients in the O group (p = 0.025 ). However, there was no significant difference regarding PSA, Gleason score, stage, or metastasis between O and non-O group (p > 0.05 ). Univariate logistic regression analyses revealed PSA, Gleason score, and blood type non-O were all correlated with high-risk PC (OR = 1.139, p < 0.001 ; OR = 9.465, p < 0.001 ; OR = 2.280, p = 0.018, resp.). In the stepwise multivariate regression analysis, the association between blood type non-O and high-risk PC remained significant (OR = 33.066, 95% CI 2.391–457.323, and p = 0.009 ) after adjusting for confounding factors as well as PSA and Gleason score. Conclusion . The present study firstly demonstrated that non-O blood type was at higher risk of aggressive PC compared with O type, suggesting that PC patients with non-O blood type should receive more attention in clinical practice.