Schizotypy, neuroticism, and saccadic eye movements: New data and meta‐analysis. (23rd October 2020)

• Record Type: Journal Article
• Authors: Thomas, Elizabeth H. X.; Steffens, Maria; Harms, Christopher; Rossell, Susan L.; Gurvich, Caroline; Ettinger, Ulrich
• Is Part Of: Psychophysiology. Volume 58:Number 1(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-10-23
• Subjects: meta‐analysis -- oculomotor control -- saccades -- schizophrenia -- schizotypy -- SPQ; Psychophysiology -- Periodicals; 612.8
• DOI: 10.1111/psyp.13706
• Languages: English
• ISSNs: 0048-5772

Abstract

Abstract: Deficits on saccade tasks, particularly antisaccade performance, have been reliably reported in schizophrenia. However, less evidence is available on saccade performance in relation to schizotypy, a personality constellation harboring risk for schizophrenia. Here, we report a large empirical study of the associations of schizotypy and neuroticism with antisaccade and prosaccade performance (Study I). Additionally, we carried out meta‐analyses of the association between schizotypy and antisaccade error rate (Study II). In Study I, N = 526 healthy individuals from the general population aged 18–54 years completed prosaccade and antisaccade tasks as well as the Schizotypal Personality Questionnaire (SPQ). Schizotypy was significantly associated with increased antisaccade error rate, with the disorganized dimension emerging as strongest predictor ( β = .118, p = .007). Neuroticism emerged as a significant predictor for prosaccade gain ( β = .103, p = .023) and antisaccade latency ( β = .101, p = .025). In Study II, random‐effects meta‐analyses were performed on the published data and those from Study I. Meta‐analyses revealed significant associations (all p ≤ .003) of antisaccade error rate with positive ( g = 0.37), negative ( g = 0.26), disorganized ( g = 0.36) and overall schizotypy ( g = 0.37). Overall, the present work replicates the association between antisaccade direction errors and schizotypy. Significant findings from meta‐analyses provide further evidence of the antisaccade error rate as a putative schizophrenia spectrum marker. Abstract : There is limited evidence on eye movement performance in relation to schizotypy, necessitating large studies, and meta‐analysis. Here, we show that schizotypy shows small yet significant associations with the direction error rate on the antisaccade task. Neuroticism, a predisposition to experience enhanced negative emotions, was associated with saccadic response speed and spatial accuracy. Significant associations between schizotypy and antisaccade errors were also obtained in meta‐analyses. Overall, we conclude that the antisaccade error rate may be a schizophrenia spectrum indicator.