Association between IL-4 and IL-4R Polymorphisms and Periodontitis: A Meta-Analysis. (14th March 2017)

• Record Type: Journal Article
• Authors: Jia, Xiao-Wei; Yuan, Ya-Di; Yao, Zhong-Xiong; Wu, Chang-Jing; Chen, Xiang; Chen, Xue-Hong; Lin, Ying-Mei; Meng, Xiang-Yu; Zeng, Xian-Tao; Shao, Jun
• Other Names: Murdaca Giuseppe Academic Editor.
• Is Part Of: Disease markers. Volume 2017(2017)
• Publication Date: 2017-03-14
• Subjects: Diagnosis -- Periodicals; Biochemical markers -- Periodicals; Pathology -- Periodicals; 616
• DOI: 10.1155/2017/8021279
• Languages: English
• ISSNs: 0278-0240

Abstract

Abstract : Background . Previous studies have revealed that gene polymorphisms of inflammatory factors may influence the development or progression of periodontitis, a main cause of tooth loss in adults; however, due to limitations of individual studies, inconsistent findings were reported. Objective . To meta-analytically investigate the relationship between periodontitis and the Interleukin-4 (IL-4) and Interleukin-4 receptor (IL-4R) gene polymorphisms. Methods . Databases were searched for relevant case-control studies. After study selection based on the predefined selection criteria, methodological quality assessment and data extraction were conducted independently by two reviewers, before subsequent statistical analyses. Results . 37 studies involving 4, 385 patients and 5, 168 controls were included. All the studied IL-4 polymorphisms were not significantly associated with periodontitis, except the -33C/T (CT versus CC: OR = 0.50, 95% CI = 0.28–0.88) associated with reduced AgP susceptibility. Positive association was found between IL-4R Q551 polymorphism and periodontitis susceptibility in three genetic models (R versus Q: OR = 1.59, 95% CI = 1.14–2.22; QR versus QQ: OR = 1.84, 95% CI = 1.21–2.80; RR + QR versus QQ: OR = 1.82, 95% CI = 1.22–2.72). Conclusions . A positive association exists between the IL-4R Q551R polymorphism and occurrence of CP. The IL-4 -33 CT genotype is negatively associated with the occurrence of AgP.