Near-Infrared Spectroscopy Reveals Abnormal Hemodynamics in the Left Dorsolateral Prefrontal Cortex of Menopausal Depression Patients. (14th February 2017)

• Record Type: Journal Article
• Authors: Ma, Xiang-Yun; Wang, Yong-Jun; Xu, Bo; Feng, Kun; Sun, Gao-Xiang; Zhang, Xiao-Qian; Liu, Xiao-Min; Shen, Chen-Yu; Ren, Xia-Jin; Sun, Jing-Jing; Liu, Po-Zi
• Other Names: Frieling Helge Academic Editor.
• Is Part Of: Disease markers. Volume 2017(2017)
• Publication Date: 2017-02-14
• Subjects: Diagnosis -- Periodicals; Biochemical markers -- Periodicals; Pathology -- Periodicals; 616
• DOI: 10.1155/2017/1695930
• Languages: English
• ISSNs: 0278-0240

Abstract

Abstract : Background/Objective . Menopausal depression (MD) is characterized by depressive symptoms along with hormonal fluctuations. We investigate brain function alteration between major depressive disorder (MDD) and MD. Methods . The difference in oxygenated hemoglobin (Oxy-Hb) for the prefrontal cortex (PFC) was compared retrospectively among 90 females presented with 30 MDD, 30 MD, and 30 healthy controls (HCs) using verbal fluency task (VFT) with near-infrared spectroscopy (NIRS). Results . We observed a significant difference in Oxy-Hb alteration in the left dorsolateral PFC (DLPFC) using VFT with NIRS (channel 18, P = 0.007 ) between the MD and MDD groups. A significant difference in Oxy-Hb levels was observed among the three groups in the bilateral DLPFC (channels 18, 27, 33, 39, 41, and 45; P < 0.05 ). Compared to the HCs, the MD group presented lower Oxy-Hb activation in the right DLPFC (channel 41; P = 0.048 ) and the left DLPFC (channels 18, 39, and 45; P < 0.05 ), and the MDD group presented lower Oxy-Hb activation in the right DLPFC (channels 27, 33, and 41; P < 0.05 ) and the left DLPFC (channels 39 and 45; P < 0.05 ). Conclusion . Abnormal hemodynamics of the left DLPFC can differentiate MD from MDD by NIRS.