Takayasu's Arteritis and Crohn's Disease in a Young Hispanic Female. (24th July 2014)

• Record Type: Journal Article
• Authors: Singh, Namrata; Saurabh, Shireesh; Tan, Irene J.
• Other Names: Alexanderson Helene Academic Editor.
• Is Part Of: Case reports in rheumatology. Volume 2014(2014)
• Publication Date: 2014-07-24
• Subjects: Rheumatology -- Periodicals; Rheumatology -- Case studies -- Periodicals; Rheumatic Diseases; Connective Tissue Diseases; Rheumatology; Periodicals; Electronic journals; Case studies; Periodicals; 616.723
• DOI: 10.1155/2014/246852
• Languages: English
• ISSNs: 2090-6889

Abstract

Abstract : Takayasu's arteritis (TA) and Crohn's disease (CD) are chronic inflammatory granulomatous disorders of undetermined etiology. TA is a large vessel vasculitis with a predilection for the aorta and its branches in young women of Asian descent; whereas CD has characteristic gastrointestinal manifestations more prevalent in young Caucasians. We describe a case of both diseases in a young Hispanic female, review the literature, and impart new insight on possible genetic linkage and the role of interleukin 12 B (IL-12B) as the common autoimmune mechanism and potential therapeutic target in this rare disease combination.