Voltammetric Study of the Antihistamine Drug Bilastine: Anodic Characterization and Quantification Using a Reusable MWCNTs Modified Screen Printed Carbon Electrode. Issue 4 (23rd November 2020)

• Record Type: Journal Article
• Authors: Teixeira, Jorge Ginja; Oliveira, João
• Is Part Of: Electroanalysis. Volume 33:Issue 4(2021)
• Page Start: 891
• Page End: 899
• Publication Date: 2020-11-23
• Subjects: Antihistamine -- Bilastine -- Multi-walled carbon nanotubes (MWCNTs) -- Screen printed carbon electrode (SPCE) -- Voltammetric determination.; Electrochemical analysis -- Periodicals; Chemistry, Analytical -- Periodicals; Electrochemistry -- Periodicals; 543.4
• DOI: 10.1002/elan.202060494
• Languages: English
• ISSNs: 1040-0397

Abstract

Abstract: The anodic behaviour and the electroanalytical quantification of the second‐generation antihistamine bilastine (BIL) were investigated for the first time. A multi‐walled carbon nanotubes (MWCNTs) film‐coated screen printed carbon electrode (SPCE), as well as cyclic (CV) and linear sweep (LSV) voltammetry, were used for that purpose. The results showed that BIL undergoes an irreversible two‐electron oxidation process at the MWCNTs‐SPCE sensor. It was also found that the sensor can be reused after a simple and rapid reconditioning procedure. The proposed method was applied to the quantification of BIL in pharmaceutical formulations and spiked urine samples, and good recoveries were obtained. Abstract :