A Case of severe mosquito bite allergy complicated by fatal hemophagocytic lymphohistiocytosis. Issue 3 (23rd March 2022)

• Record Type: Journal Article
• Authors: Dupuy, Elizabeth; Afifi, Ladan; Jonas, Steven J.; Cheng, Carol E.; Hogeling, Marcia
• Is Part Of: Pediatric dermatology. Volume 39:Issue 3(2022)
• Page Start: 443
• Page End: 446
• Publication Date: 2022-03-23
• Subjects: chronic active EBV infection -- EBV -- EBV‐associated T‐/NK‐cell lymphoproliferative disease -- hemophagocytic lymphohistiocytosis -- mosquito bite; Pediatric dermatology -- Periodicals; Children -- Diseases -- Periodicals; 618.925
• DOI: 10.1111/pde.14877
• Languages: English
• ISSNs: 0736-8046

Abstract

Abstract: Severe mosquito bite allergy (SMBA) is characterized by necrotic skin lesions and systemic symptoms. Chronic active Epstein–Barr virus (EBV) infection, when superimposed with SMBA, is a key driver for catastrophic clinical consequences, such as uncontrolled lymphoproliferation. This interplay is of clinical significance due to its association with hemophagocytic lymphohistiocytosis (HLH) and/or EBV‐driven malignancies. Here, we report a case of SMBA that developed in a 14‐year‐old Hispanic boy that led to fatal secondary HLH.