Interaction of a Jaundice Marker Molecule with a Redox‐Modulatory Nano‐Hybrid: A Combined Electrochemical and Spectroscopic Study toward the Development of a Theranostic Tool. (9th February 2022)

• Record Type: Journal Article
• Authors: Mondal, Susmita; Pan, Nivedita; Ghosh, Ria; Bera, Arpan; Mukherjee, Dipanjan; Maji, Tuhin Kumar; Adhikari, Anirudddha; Ghosh, Sangeeta; Bhattacharya, Chinmoy; Pal, Samir Kumar
• Is Part Of: ChemMedChem. Volume 17:Number 14(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-02-09
• Subjects: theranostics -- citrate functionalized Mn3O4 nanohybrid -- jaundice -- redox modulation -- electrochemical sensor; Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.1002/cmdc.202100660
• Languages: English
• ISSNs: 1860-7179

Abstract

Abstract: This study explores a combined electrochemical and spectroscopic approach to investigate the degradation of bilirubin, a molecular marker of jaundice in humans using a biocompatible nanohybrid (citrate‐functionalized Mn3 O4 nanohybrid; C−Mn3 O4 NH). The approach is aimed at the development of a facile theranostic tool for treatment, detection, and prognosis of jaundice. Linear sweep voltammetry (LSV) studies on bilirubin, C−Mn3 O4 NH, a model carrier protein, and its complex with bilirubin reveal the efficacy of the nanohybrid for both degradation and detection of bilirubin. Furthermore, spectroscopic studies depict that distal electron transfer to be the probable mechanism behind the observed bilirubin degradation in physiological milieu. Abstract : Diagnostic possibilities : A newly developed theranostic strategy utilizes functional nanohybrid‐induced reactive oxygen species (ROS) as therapeutic agents against hyperbilirubinemia. Corresponding changes in ROS concentrations as an indication of therapeutic efficacy is reflected in the chronoamperometric and spectroscopic analysis and offers diagnostic possibilities.