Molecular Imaging to Predict Response to Targeted Therapies in Renal Cell Carcinoma. (9th April 2017)

• Record Type: Journal Article
• Authors: Leguerney, Ingrid; de Rochefort, Ludovic; Poirier-Quinot, Marie; Ingels, Alexandre; Violas, Xavier; Robin, Sandra; Opolon, Paule; Dubuisson, Rose-Marie; Pitre-Champagnat, Stéphanie; Robert, Philippe; Lassau, Nathalie
• Other Names: Roivainen Anne Academic Editor.
• Is Part Of: Contrast media & molecular imaging. Volume 2017(2017)
• Publication Date: 2017-04-09
• Subjects: Diagnostic imaging -- Periodicals; Magnetic resonance imaging -- Periodicals; Contrast media (Diagnostic imaging) -- Periodicals; Contrast Media -- Periodicals; Diagnostic Imaging -- Periodicals; Substances de contraste -- Périodiques; Diagnostics moléculaires -- Périodiques; Imagerie médicale; Substance de contraste; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.0754
• DOI: 10.1155/2017/7498538
• Languages: English
• ISSNs: 1555-4309

Abstract

Abstract : Molecular magnetic resonance imaging targeted to an endothelial integrin involved in neoangiogenesis was compared to DCE-US and immunochemistry to assess the early response of three different therapeutic agents in renal cell carcinoma. Human A498 renal cells carcinoma was subcutaneously inoculated into 24 nude mice. Mice received either phosphate-buffered saline solution, sunitinib, everolimus, or bevacizumab during 4 days. DCE-US and molecular MRI targeting α v β 3 were performed at baseline and 4 days after treatment initiation. PI, AUC, relaxation rate variations Δ R 2 ⁎, and percentage of vessels area quantified on CD31-stained microvessels were compared. Significant decreases were observed for PI and AUC parameters measured by DCE-US for bevacizumab group as early as 4 days, whereas molecular α v β 3-targeted MRI was able to detect significant changes in both bevacizumab and everolimus groups. Percentage of CD31-stained microvessels was significantly correlated with DCE-US parameters, PI (R = 0.87, p = 0.0003 ) and AUC (R = 0.81, p = 0.0013 ). The percentage of vessel tissue area was significantly reduced (p < 0.01 ) in both sunitinib and bevacizumab groups. We report an early detection of neoangiogenesis modification after induction of targeted therapies, using DCE-US or α v β 3-targeted MRI. We consider these outcomes should encourage clinical trial developments to further evaluate the potential of this molecular MRI technique.