Association between metabolic syndrome and left ventricular geometric change including diastolic dysfunction. Issue 7 (3rd May 2022)

• Record Type: Journal Article
• Authors: Lee, Seung‐Jae; Kim, Hyunah; Oh, Byeong Kil; Choi, Hyo‐In; Sung, Ki‐Chul; Kang, Jeonggyu; Lee, Mi Yeon; Lee, Jong‐Young
• Is Part Of: Clinical cardiology. Volume 45:Issue 7(2022)
• Page Start: 767
• Page End: 777
• Publication Date: 2022-05-03
• Subjects: diastolic dysfunction -- echocardiography -- heart failure -- left ventricle -- metabolic syndrome -- relaxation function -- sex difference; Cardiology -- Periodicals; 616.12005
• DOI: 10.1002/clc.23838
• Languages: English
• ISSNs: 0160-9289

Abstract

Abstract: Background: We investigated the association between individual components of metabolic syndrome (MetS) and left ventricular (LV) geometric changes, including diastolic dysfunction, in a large cohort of healthy individuals. Methods: Overall, 148 461 adults who underwent echocardiography during a health‐screening program were enrolled. Geographic characteristics on echocardiography and several markers of LV relaxation function were identified according to individual MetS components. Univariate linear regression analysis and a multivariate regression model adjusted for factors known to influence LV relaxation function were conducted. Results: The prevalence of LV diastolic dysfunction (LVDD) was higher in the MetS group than in the non‐MetS group (0.56% vs. 0.27%, p < .001). In univariate and multivariate analyses, E/A ratio, e′ velocity, and left atrial volume index were significantly associated with each component of MetS and covariates (all p ≤ .001). In the age‐ and sex‐adjusted model, MetS was significantly associated with LVDD (odds ratio [95% confidence interval], 1.350 [1.103, 1.652]). However, subjects with more MetS components did not have a significantly higher risk of LVDD. As the analysis was stratified by sex, the multivariate regression model showed that MetS was significantly associated with LVDD only in men (1.3 [1.00, 1.68]) with higher risk in more MetS component ( p for trend < .001). In particular, triglyceride (TG) and waist circumference (WC) among MetS components were significantly associated with LVDD in men. Conclusions: MetS was associated with the risk of LVDD, especially in men, with a dose‐dependent association between an increasing number of components of MetS and LVDD. TG and WC were independent risk factors for LVDD in men.