Long‐Acting Protective Ocular Surface by Instilling Adhesive Dual‐Antiviral Nanoparticles. Issue 14 (27th May 2022)

• Record Type: Journal Article
• Authors: Wang, Xinyue; Chen, Liangbo; Wang, Xinling; Zhang, Mengmeng; Yang, Fengmin; Wu, Feng; Liu, Jinyao; Lu, Lu; Pang, Yan
• Is Part Of: Advanced healthcare materials. Volume 11:Issue 14(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-05-27
• Subjects: SARS‐CoV‐2 -- adhesives -- antivirals -- nanoparticles -- ocular surfaces; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202200283
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: The eye is susceptible to viral infections, causing severe ocular symptoms or even respiratory diseases. Methods capable of protecting the eye from external viral invasion in a long‐term and highly effective way are urgently needed but have been proved to be extremely challenging. Here, a strategy of forming a long‐acting protective ocular surface is described by instilling adhesive dual‐antiviral nanoparticles. Taking pseudotyped severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) as a model virus, antiviral agent‐loaded nanoparticles are coated with a "double‐lock" hybrid cell membrane abundant with integrin‐ β 1 and angiotensin converting enzyme II (ACE2). After instillation, the presence of integrin‐ β 1 endows coated nanoparticles with steady adhesion via specific binding to Arg‐Gly‐Asp sequence on the fibronectin of ocular epithelium, achieving durable retention on the ocular surface. In addition to loaded inhibitors, the exposure of ACE2 can trap SARS‐CoV‐2 and subsequently neutralize the associated spike protein, playing a dual antiviral effect of the resulting nanoparticles. Adhesive dual‐antiviral nanoparticles enabled by coating with a "double‐lock" hybrid cell membrane could be a versatile platform for topical long‐acting protection against viral infection of the eye. Abstract : Methods capable of protecting the eye from external viral invasion in a long‐term and highly effective way are urgently needed but have been proved to be extremely challenging. In this work, a strategy is described of forming a long‐acting protective ocular surface by instilling adhesive dual‐antiviral nanoparticles, which are enabled by coating with a "double‐lock" hybrid cell membrane.