Head-to-Head Comparison of 68Ga-Citrate and 18F-FDG PET/CT for Detection of Infectious Foci in Patients with Staphylococcus aureus Bacteraemia. (17th October 2017)

• Record Type: Journal Article
• Authors: Salomäki, Soile P.; Kemppainen, Jukka; Hohenthal, Ulla; Luoto, Pauliina; Eskola, Olli; Nuutila, Pirjo; Seppänen, Marko; Pirilä, Laura; Oksi, Jarmo; Roivainen, Anne
• Other Names: Rösch Frank Academic Editor.
• Is Part Of: Contrast media & molecular imaging. Volume 2017(2017)
• Publication Date: 2017-10-17
• Subjects: Diagnostic imaging -- Periodicals; Magnetic resonance imaging -- Periodicals; Contrast media (Diagnostic imaging) -- Periodicals; Contrast Media -- Periodicals; Diagnostic Imaging -- Periodicals; Substances de contraste -- Périodiques; Diagnostics moléculaires -- Périodiques; Imagerie médicale; Substance de contraste; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.0754
• DOI: 10.1155/2017/3179607
• Languages: English
• ISSNs: 1555-4309

Abstract

Abstract : Purpose . This study evaluated the potential of 68 Ga-citrate positron emission tomography/computed tomography (PET/CT) for the detection of infectious foci in patients with Staphylococcus aureus bacteraemia by comparing it with 2-[ 18 F]fluoro-2-deoxy-D -glucose ( 18 F-FDG) PET/CT. Methods. Four patients admitted to hospital due to S. aureus bacteraemia underwent both 18 F-FDG and 68 Ga-citrate whole-body PET/CT scans to detect infectious foci. Results. The time from hospital admission and the initiation of antibiotic treatment to the first PET/CT was 4–10 days. The time interval between 18 F-FDG and 68 Ga-citrate PET/CT was 1–4 days. Three patients had vertebral osteomyelitis (spondylodiscitis) and one had osteomyelitis in the toe; these were detected by both 18 F-FDG (maximum standardised uptake value [S U V m a x ] 6.0 ± 1.0 ) and 68 Ga-citrate (S U V m a x 6.8 ± 3.5, P = 0.61 ). Three patients had soft tissue infectious foci, with more intense 18 F-FDG uptake (S U V m a x 6.5 ± 2.5 ) than 68 Ga-citrate uptake (S U V m a x 3.9 ± 1.2, P = 0.0033 ). Conclusions. Our small cohort of patients with S. aureus bacteraemia revealed that 68 Ga-citrate PET/CT is comparable to 18 F-FDG PET/CT for detection of osteomyelitis, whereas 18 F-FDG resulted in a higher signal for the detection of soft tissue infectious foci.