Current understanding and future implications of sepsis‐induced thrombocytopenia. (29th November 2020)

• Record Type: Journal Article
• Authors: Ghimire, Subash; Ravi, Swapna; Budhathoki, Rasmita; Arjyal, Lubina; Hamal, Savyata; Bista, Amir; Khadka, Sushmita; Uprety, Dipesh
• Is Part Of: European journal of haematology. Volume 106:Number 3(2021)
• Page Start: 301
• Page End: 305
• Publication Date: 2020-11-29
• Subjects: sepsis -- sepsis‐induced thrombocytopenia -- thrombocytopenia; Hematology -- Periodicals; Blood -- Diseases -- Periodicals; Blood -- Periodicals; 616.15005
• DOI: 10.1111/ejh.13549
• Languages: English
• ISSNs: 0902-4441

Abstract

Abstract: Sepsis is a global health burden that needs intensive medical care. Thrombocytopenia in sepsis is well known to increase morbidity as well as mortality. Several studies have been performed both in animal models and in humans to understand the mechanism by which sepsis causes thrombocytopenia. Recent studies have shown that inhibiting thrombocytopenia improves outcomes in sepsis patients. Understanding these mechanisms to identify targets in use of newer treatment modalities besides using resuscitation measures, antibiotics and removal of thrombocytopenia inducing agent could potentially help us improve outcomes in sepsis.