Advancing Tissue Decellularized Hydrogels for Engineering Human Organoids. (22nd May 2022)
- Record Type:
- Journal Article
- Title:
- Advancing Tissue Decellularized Hydrogels for Engineering Human Organoids. (22nd May 2022)
- Main Title:
- Advancing Tissue Decellularized Hydrogels for Engineering Human Organoids
- Authors:
- Moura, Beatriz S.
Monteiro, Maria V.
Ferreira, Luís P.
Lavrador, Pedro
Gaspar, Vítor M.
Mano, João F. - Abstract:
- Abstract: The extracellular matrix plays a critical role in bioinstructing cellular self‐assembly and spatial (re)configuration processes that culminate in human organoids in vitro generation and maturation. Considering the importance of the supporting matrix, herein is showcased the most recent advances in the bioengineering of decellularized tissue hydrogels for generating organoids and assembloids. Key design blueprints, characterization methodologies, and extracellular matrix processing toolboxes are comprehensively discussed in light of current advances. Such enabling approaches provide the grounds for engineering next‐generation tissue‐specific hydrogels with close‐to‐native biomolecular signatures and user‐tailored biophysical properties that may potentiate organoids physiomimetic potential. In a forward looking perspective, the combination of tissue‐specific decellularized hydrogels with increasingly complex multicellular assemblies and bottom‐up cell engineering technologies may unravel unprecedented tissue‐like physiological responses and further advance the exploitation of organoids and assembloids as human disease surrogates or as patient‐tailored living therapeutics. Abstract : Bioengineered decellularized tissue hydrogels arise as close‐to‐native supporting matrices for leveraging organoids and assembloids with enhanced and unprecedented physiomimetic and biological potential, further advancing their exploitation as patient‐specific disease models and livingAbstract: The extracellular matrix plays a critical role in bioinstructing cellular self‐assembly and spatial (re)configuration processes that culminate in human organoids in vitro generation and maturation. Considering the importance of the supporting matrix, herein is showcased the most recent advances in the bioengineering of decellularized tissue hydrogels for generating organoids and assembloids. Key design blueprints, characterization methodologies, and extracellular matrix processing toolboxes are comprehensively discussed in light of current advances. Such enabling approaches provide the grounds for engineering next‐generation tissue‐specific hydrogels with close‐to‐native biomolecular signatures and user‐tailored biophysical properties that may potentiate organoids physiomimetic potential. In a forward looking perspective, the combination of tissue‐specific decellularized hydrogels with increasingly complex multicellular assemblies and bottom‐up cell engineering technologies may unravel unprecedented tissue‐like physiological responses and further advance the exploitation of organoids and assembloids as human disease surrogates or as patient‐tailored living therapeutics. Abstract : Bioengineered decellularized tissue hydrogels arise as close‐to‐native supporting matrices for leveraging organoids and assembloids with enhanced and unprecedented physiomimetic and biological potential, further advancing their exploitation as patient‐specific disease models and living therapeutics. This review delineates the most recent advances in the design and bioengineering of such hydrogels, discussing their improvement and upscaling path toward their application in the clinic. … (more)
- Is Part Of:
- Advanced functional materials. Volume 32:Number 29(2022)
- Journal:
- Advanced functional materials
- Issue:
- Volume 32:Number 29(2022)
- Issue Display:
- Volume 32, Issue 29 (2022)
- Year:
- 2022
- Volume:
- 32
- Issue:
- 29
- Issue Sort Value:
- 2022-0032-0029-0000
- Page Start:
- n/a
- Page End:
- n/a
- Publication Date:
- 2022-05-22
- Subjects:
- assembloids -- decellularized extracellular matrixes -- disease models -- organoids -- tissue engineering
Materials -- Periodicals
Chemical vapor deposition -- Periodicals
620.11 - Journal URLs:
- http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1616-3028 ↗
http://onlinelibrary.wiley.com/ ↗ - DOI:
- 10.1002/adfm.202202825 ↗
- Languages:
- English
- ISSNs:
- 1616-301X
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 0696.853900
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 22625.xml