Immune Response to Lipoproteins in Atherosclerosis. (23rd August 2012)

• Record Type: Journal Article
• Authors: Samson, Sonia; Mundkur, Lakshmi; Kakkar, Vijay V.
• Other Names: Ibrahim Michael Academic Editor.
• Is Part Of: Cholesterol. Volume 2012(2012)
• Publication Date: 2012-08-23
• Subjects: Cholesterol -- Periodicals; Cholesterol -- Metabolism -- Periodicals; Cholesterol -- Health aspects -- Periodicals; Coronary heart disease -- Prevention -- Periodicals; 612.0157705
• DOI: 10.1155/2012/571846
• Languages: English
• ISSNs: 2090-1283

Abstract

Abstract : Atherosclerosis, the underlying cause of cardiovascular disease, is characterized by chronic inflammation and altered immune response. Cholesterol is a well-known risk factor associated with the development of cardiovascular diseases. Elevated serum cholesterol is unique because it can lead to development of atherosclerosis in animals and humans even in the absence of other risk factors. Modifications of low-density lipoproteins mediated by oxidation, enzymatic degradation, and aggregation result in changes in their function and activate both innate and adaptive immune system. Oxidized low-density lipoprotein (LDL) has been identified as one of the most important autoantigens in atherosclerosis. This escape from self-tolerance is dependent on the formation of oxidized phospholipids. The emerging understanding of the importance of immune responses against oxidized LDL in atherosclerosis has focused attention on the possibility of development of novel therapy for atherosclerosis. This review provides an overview of immune response to lipoproteins and the fascinating possibility of developing an immunomodulatory therapy for atherosclerosis.