Bifurcations and Dynamics of the Rb-E2F Pathway Involving miR449. (19th October 2017)

• Record Type: Journal Article
• Authors: Li, Lingling; Shen, Jianwei
• Other Names: Lakshmanan Shanmugam Academic Editor.
• Is Part Of: Complexity. Volume 2017(2017)
• Publication Date: 2017-10-19
• Subjects: Chaotic behavior in systems -- Periodicals; Complexity (Philosophy) -- Periodicals; 003
• DOI: 10.1155/2017/1409865
• Languages: English
• ISSNs: 1076-2787

Abstract

Abstract : We focused on the gene regulative network involving Rb-E2F pathway and microRNAs (miR449) and studied the influence of time delay on the dynamical behaviors of Rb-E2F pathway by using Hopf bifurcation theory. It is shown that under certain assumptions the steady state of the delay model is asymptotically stable for all delay values; there is a critical value under another set of conditions; the steady state is stable when the time delay is less than the critical value, while the steady state is changed to be unstable when the time delay is greater than the critical value. Thus, Hopf bifurcation appears at the steady state when the delay passes through the critical value. Numerical simulations were presented to illustrate the theoretical results.