Novel gammaherpesvirus associated with primary gastric T‐cell lymphoma in a free‐ranging giant armadillo in Brazil. Issue 4 (24th June 2021)

• Record Type: Journal Article
• Authors: Navas‐Suárez, Pedro Enrique; Sacristán, Carlos; Kluyber, Danilo; Yogui, Débora Regina; Alves, Amanda Carolina; Dalazen, Gislaine Taimara; Díaz‐Delgado, Josué; Guerra, Juliana Mariotti; de Azevedo Fernandes, Natália Coelho Couto; Réssio, Rodrigo Albergaria; da Silva, Tereza Cristina; Cogliati, Bruno; Desbiez, Arnaud Leonard Jean; Catão‐Dias, José Luiz
• Is Part Of: Transboundary and emerging diseases. Volume 69:Issue 4(2022)
• Page Start: 2045
• Page End: 2051
• Publication Date: 2021-06-24
• Subjects: Brazil -- cancer -- cingulata -- virus discovery -- wildlife; Veterinary medicine -- Periodicals; 636.089
• DOI: 10.1111/tbed.14189
• Languages: English
• ISSNs: 1865-1674

Abstract

Abstract: The number of viral‐associated neoplasms reported in wildlife has increased over the last decades, likely because of growing research efforts and a potentially greater burden of carcinogenic pathogens. Herein, we describe a primary gastric T‐cell lymphoma in one free‐ranging giant armadillo ( Priodontes maximus ) from Brazilian Pantanal infected by a novel gammaherpesvirus, proposed as Cingulatid gammaherpesvirus 1 (CiHV‐1). By chromogenic in situ hybridisation against Epstein–Barr virus some neoplastic cells were labeled. Subsequently, a molecular screening was carried out to detect the occurrence of this pathogen in other giant armadillos in the same region. Overall, this novel virus was detected in 14.3% (3/21) of the tested giant armadillos. We suggest this herpesvirus, the first in Xenarthra, as a plausible aetiology of the neoplasm. The implications of CiHV‐1 for this species are uncertain; while no outbreaks of disease have been recorded, the present study raises concerns. Further research is warranted to assess the real significance of CiHV‐1 and its potential oncogenic role in this species.