Conceptual framework for the definition of preclinical and prodromal frontotemporal dementia. Issue 7 (7th December 2021)

• Record Type: Journal Article
• Authors: Benussi, Alberto; Alberici, Antonella; Samra, Kiran; Russell, Lucy L.; Greaves, Caroline V.; Bocchetta, Martina; Ducharme, Simon; Finger, Elizabeth; Fumagalli, Giorgio; Galimberti, Daniela; Jiskoot, Lize C.; Le Ber, Isabelle; Masellis, Mario; Nacmias, Benedetta; Rowe, James B.; Sanchez‐Valle, Raquel; Seelaar, Harro; Synofzik, Matthis; Rohrer, Jonathan D.; Borroni, Barbara
• Other Names: Afonso Sónia investigator.; Almeida Maria Rosario investigator.; Anderl‐Straub Sarah investigator.; Andersson Christin investigator.; Antonell Anna investigator.; Archetti Silvana investigator.; Arighi Andrea investigator.; Balasa Mircea investigator.; Barandiaran Myriam investigator.; Bargalló Nuria investigator.; Bartha Robart investigator.; Bender Benjamin investigator.; Bertoux Maxime investigator.; Bertrand Anne investigator.; Bessi Valentina investigator.; Black Sandra investigator.; Borrego‐Ecija Sergi investigator.; Bouzigues Arabella investigator.; Bras Jose investigator.; Brice Alexis investigator.; Bruffaerts Rose investigator.; Butler Chris R. investigator.; Camuzat Agnès investigator.; Cañada Marta investigator.; Cantoni Valentina investigator.; Caroppo Paola investigator.; Cash David investigator.; Castelo‐Branco Miguel investigator.; Colliot Olivier investigator.; Convery Rhian investigator.; Cope Thomas investigator.; Danek Adrian investigator.; de Mendonça Alexandre investigator.; Deramecourt Vincent investigator.; Di Fede Giuseppe investigator.; Díez Alina investigator.; Duro Diana investigator.; Fenoglio Chiara investigator.; Ferrari Camilla investigator.; Ferreira Catarina B. investigator.; Fox Nick investigator.; Freedman Morris investigator.; Funkiewiez Aurélie investigator.; Gabilondo Alazne investigator.; Gauthier Serge investigator.; Gazzina Stefano investigator.; Gerhard Alexander investigator.; Giaccone Giorgio investigator.; Gorostidi Ana investigator.; Graff Caroline investigator.; Guerreiro Rita investigator.; Heller Carolin investigator.; Hoegen Tobias investigator.; Indakoetxea Begoña investigator.; Jelic Vesna investigator.; Karnath Hans‐Otto investigator.; Keren Ron investigator.; Kuchcinski Gregory investigator.; Laforce Robert investigator.; Waldo Maria Landqvist investigator.; Langheinrich Tobias investigator.; Lebouvier Thibaud investigator.; Leitão Maria João investigator.; Levin Johannes investigator.; Lladó Albert investigator.; Lombardi Gemma investigator.; Lombardi Jolina investigator.; Loosli Sandra investigator.; Maruta Carolina investigator.; Mead Simon investigator.; Meeter Lieke investigator.; Miltenberger Gabriel investigator.; van Minkelen Rick investigator.; Mitchell Sara investigator.; Moore Katrina investigator.; Moreno Fermin investigator.; Nelson Annabel investigator.; Nicholas Jennifer investigator.; Öijerstedt Linn investigator.; Olives Jaume investigator.; Otto Markus investigator.; Ourselin Sebastien investigator.; Panman Jessica investigator.; Papma Janne M. investigator.; Pasquier Florence investigator.; Pijnenburg Yolande investigator.; Polito Cristina investigator.; Premi Enrico investigator.; Prioni Sara investigator.; Prix Catharina investigator.; Rademakers Rosa investigator.; Redaelli Veronica investigator.; Rinaldi Daisy investigator.; Rittman Tim investigator.; Rogaeva Ekaterina investigator.; Rollin Adeline investigator.; Rosa‐Neto Pedro investigator.; Rossi Giacomina investigator.; Rossor Martin investigator.; Santana Isabel investigator.; Santiago Beatriz investigator.; Saracino Dario investigator.; Sayah Sabrina investigator.; Scarpini Elio investigator.; Schönecker Sonja investigator.; Schroeter Matthias investigator.; Shafei Rachelle investigator.; Shoesmith Christen investigator.; Sorbi Sandro investigator.; Swift Imogen investigator.; Tábuas‐Pereira Miguel investigator.; Pijnenburg Yolande investigator.; Tagliavini Fabrizio investigator.; Tainta Mikel investigator.; Taipa Ricardo investigator.; Tang‐Wai David investigator.; Tartaglia Carmela investigator.; Thomas David L. investigator.; Thompson Paul investigator.; Thonberg Hakan investigator.; Timberlake Carolyn investigator.; Tiraboschi Pietro investigator.; Todd Emily investigator.; Van Damme Philip investigator.; Vandenberghe Rik investigator.; Vandenbulcke Mathieu investigator.; van Swieten John C. investigator.; Veldsman Michele investigator.; Verdelho Ana investigator.; Villanua Jorge investigator.; Warren Jason investigator.; Wilke Carlo investigator.; Woollacott Ione investigator.; Wlasich Elisabeth investigator.; Zetterberg Henrik investigator.; Zulaica Miren investigator.;
• Is Part Of: Alzheimer's & dementia. Volume 18:Issue 7(2022)
• Page Start: 1408
• Page End: 1423
• Publication Date: 2021-12-07
• Subjects: definition -- frontotemporal dementia -- frontotemporal lobar degeneration -- mild cognitive and/or behavioral and/or motor impairment -- mild cognitive impairment -- preclinical -- presymptomatic -- prodromal; Alzheimer's disease -- Periodicals; Alzheimer Disease -- Periodicals; Dementia -- Periodicals; Démence; Maladie d'Alzheimer; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.83
• DOI: 10.1002/alz.12485
• Languages: English
• ISSNs: 1552-5260

Abstract

Abstract: The presymptomatic stages of frontotemporal dementia (FTD) are still poorly defined and encompass a long accrual of progressive biological (preclinical) and then clinical (prodromal) changes, antedating the onset of dementia. The heterogeneity of clinical presentations and the different neuropathological phenotypes have prevented a prior clear description of either preclinical or prodromal FTD. Recent advances in therapeutic approaches, at least in monogenic disease, demand a proper definition of these predementia stages. It has become clear that a consensus lexicon is needed to comprehensively describe the stages that anticipate dementia. The goal of the present work is to review existing literature on the preclinical and prodromal phases of FTD, providing recommendations to address the unmet questions, therefore laying out a strategy for operationalizing and better characterizing these presymptomatic disease stages.