Receptor‐Level Proximity and Fastening of Ligands Modulates Stem Cell Differentiation (Adv. Funct. Mater. 30/2022). (25th July 2022)

• Record Type: Journal Article
• Authors: Bae, Gunhyu; Kim, Myeong Soo; Thangam, Ramar; Koo, Thomas Myeongseok; Jang, Woo Young; Yoon, Jinho; Han, Seong‐Beom; Yang, Letao; Kim, Seong Yeol; Kang, Nayeon; Min, Sunhong; Hong, Hyunsik; Fu, Hong En; Ko, Min Jun; Kim, Dong‐Hwee; Jeong, Woong Kyo; Kim, Dong‐Hyun; Kim, Tae‐Hyung; Choi, Jeong‐Woo; Lee, Ki‐Bum; Paulmurugan, Ramasamy; Zhu, Yangzhi; Kim, Han‐Jun; Lee, Junmin; Kim, Jong Seung; Khademhosseini, Ali; Kim, Young Keun; Kang, Heemin
• Is Part Of: Advanced functional materials. Volume 32:Number 30(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-07-25
• Subjects: integrin clustering -- ligand fastening -- ligand proximity -- stem cell adhesion -- stem cell differentiation; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.202270170
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract : Integrin Clustering In article number 2200828, Young Keun Kim, Heemin Kang, and co‐workers report the dynamic tuning of receptor‐level ligand proximity. Closely spaced ligands coated onto subordinate nanostructures distributed on a nano‐template stimulate integrin binding and clustering. This activates the spreading, mechanotransduction, and differentiation of stem cells that occur in an active pro‐regenerative microenvironment.