Two New Nor‐seco‐Isodhilarane‐Type Meroterpenoids from the Endophytic Fungus Penicillium purpurogenum. Issue 7 (8th June 2022)

• Record Type: Journal Article
• Authors: Zhang, Ying; Xia, Gui‐Yang; Wu, Yu‐Zhuo; Wei, Xiao‐Hong; Xia, Huan; Wang, Ling‐Yan; Lin, Peng‐Cheng; Wang, Ya‐Nan; Chen, Li‐Xia; Lin, Sheng
• Is Part Of: Chemistry & biodiversity. Volume 19:Issue 7(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-06-08
• Subjects: Penicillium purpurogenum -- meroterpenoids -- purpurogenolide F -- purpurogenolide G -- anti-inflammatory activity; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Biodiversity -- Periodicals; 572
• DOI: 10.1002/cbdv.202200403
• Languages: English
• ISSNs: 1612-1872

Abstract

Abstract: Two new nor‐ seco isodhilarane meroterpenoids (NSIMs), purpurogenolides F (1 ) and G (2 ), along with three known meroterpenoid analogs (3 –5 ), were isolated from the cultures of an endophytic fungus, Penicillium purpurogenum . Structures and absolute configurations of the new NSIMs were determined based on extensive spectroscopic data analyses, including HR‐ESI‐MS, UV, IR, NMR chemical shift calculations together with DP4+ probability analysis, as well as ECD calculations. All the isolated meroterpenoids were assessed for their anti‐inflammatory activities, and compound 4 exhibited moderate inhibitory activity against the nitric oxide (NO) production in lipopolysaccharide (LPS) induced RAW 264.7 cells with an IC50 value of 20.85±2.31 μM. Abstract :