Different aspects of polymers – A review article. (2022)

• Record Type: Journal Article
• Authors: Bhatt, Shubham; Pathak, Anuj; Grover, Parul; Bharadwaj, Abhay; Bhatia, Daksh; Tomar, Ritu; Kaurav, Monika
• Is Part Of: Materials today. Volume 64:Part 3(2022)
• Page Start: 1490
• Page End: 1495
• Publication Date: 2022
• Subjects: Biocompatibility -- Biodegradability -- Biomedical -- Drug Delivery systems, Implantations -- Polymer Conjugates; CT Computed Tomography -- DNA Deoxyribonucleic acid, DSC, Differential scanning Calorimetry -- DMA Dynamic mechanical analysis -- FDA Food & Drug Administration, GCSF, Granulocyte colony stimulating factors -- HPMC Hydroxypropyl methylcellulose -- LDH Lactic acid dehydrogenase -- MRI Magnetic Resonance Imaging -- NADH Nicotinamide adenine dinucleotide -- NDDS Novel drug delivery system -- PAI Photoacoustic Imaging -- PEG Polyethylene glycol -- PUMPT Polymer Masking Unmasking Protein Therapy -- RI Radionuclide Imaging -- MTT Succinate dehydrogenase activity -- UV Ultraviolet; Materials science -- Congresses -- Periodicals; 620.1
• DOI: 10.1016/j.matpr.2022.04.926
• Languages: English
• ISSNs: 2214-7853

Abstract

Abstract: Polymers play vital roles in the dosage developments of immediate release dosage forms and modified release dosage forms. In different drug delivery systems, polymers are used to develop the dosage forms which are designed to control the release of the therapeutic agent at a constant dose for long time intervals that decrease the cyclic dosages. It is widely used as excipients in formulating various dosage designs to aid the bulk amount so that the drug gets trapped. Immediate-release dosage forms consist of tablets and capsules and modified release dosage forms consist of extended-release dosage forms and gastro retentive release dosage forms. Different modifications are performed with polymers to make conjugates such as polymer-drug and polymer-protein conjugates which are widely used as polymeric carriers in biological applications. Polymers are the backbones of pharmaceuticals drug delivery that are designed to control drugs released through different medical devices such as implants. In biological applications, biodegradable polymers are widely due to having good biocompatibility properties with other therapeutic agents and well-known biodegradability properties. It provides resistance to the drugs from the biological environment and prolongs the drug's release so that it achieves its stability. Different biocompatibility tests are performed in-vivo and in-vitro for both natural as well as synthetic biodegradable polymers that are used in the dosage form and biomedical applications.