Photocatalyzed gem‐Difluoroallylation of Tertiary Amines with α‐Trifluoromethyl Alkenes. Issue 26 (8th July 2022)

• Record Type: Journal Article
• Authors: Yang, Chunhui; Chen, Jingchao; Li, Xinhan; Yang, Xiaoju; Zhu, Yuanbin; Wu, Shiyuan; Zeng, Guangzhi; Wang, Kaimin; Fan, Baomin
• Is Part Of: ChemistrySelect. Volume 7:Issue 26(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-07-08
• Subjects: Difluoroallylation -- Tertiary amine -- α-Trifluoromethyl alkene -- Difluoroalkene -- Defluorination; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.202201188
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: The gem ‐difluoroalkene moiety has attracted considerable attention from the synthetic chemistry community due to its outstanding performance in the drug design and development. By employing 4‐CzIPN as photocatalyst, a metal‐free synthetic method for gem ‐difluoroalkenes is developed under blue LED irradiation. A wide range of tertiary amines and α‐trifluoromethyl alkenes are applicable in the present gem ‐difluoroallylation and successfully transformed into the gem ‐difluoroalkenes in good yields. Abstract : The gem ‐difluoroalkene moiety has attracted considerable attention from the synthetic chemistry community due to its outstanding performance in the drug design and development. By employing 4‐CzIPN as photocatalyst, a metal‐free synthetic method for gem ‐difluoroalkenes is developed under blue LED irradiation. A wide range of tertiary amines and α‐trifluoromethyl alkenes are applicable in the present gem ‐difluoroallylation and successfully transformed into the gem ‐difluoroalkenes in good yields.