Human Mesenchymal Stem Cell‐Derived Miniature Joint System for Disease Modeling and Drug Testing (Adv. Sci. 21/2022). Issue 21 (25th July 2022)

• Record Type: Journal Article
• Authors: Li, Zhong; Lin, Zixuan; Liu, Silvia; Yagi, Haruyo; Zhang, Xiurui; Yocum, Lauren; Romero‐Lopez, Monica; Rhee, Claire; Makarcyzk, Meagan J.; Yu, Ilhan; Li, Eileen N.; Fritch, Madalyn R.; Gao, Qi; Goh, Kek Boon; O'Donnell, Benjamen; Hao, Tingjun; Alexander, Peter G.; Mahadik, Bhushan; Fisher, John P.; Goodman, Stuart B.; Bunnell, Bruce A.; Tuan, Rocky S.; Lin, Hang
• Is Part Of: Advanced science. Volume 9:Issue 21(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-07-25
• Subjects: Science -- Periodicals; 505
• DOI: 10.1002/advs.202270133
• Languages: English
• ISSNs: 2198-3844

Abstract

Abstract : Human Mesenchymal Stem Cell‐Derived Miniature Joint System In article number 2105909 by Rocky S. Tuan, Hang Lin, and co‐workers, a miniature synovial joint‐mimicking system (miniJoint) is established in a microfluidics‐enabled bioreactor, in which human mesenchymal stem cell‐derived bone‐cartilage complex, synovial‐like fibrous tissue, and adipose tissue are integrated and show active crosstalk. The data demonstrate the potential of miniJoint as a new model for the study of joint pathology and the development of novel therapeutic interventions.