Two Cases of Sinonasal Non-Intestinal-Type Adenocarcinoma with Squamoid Morules Expressing Nuclear β-Catenin and CDX2: A Curious Morphologic Finding Supported by Molecular Analysis. (13th September 2018)

• Record Type: Journal Article
• Authors: Villatoro, Tatiana M.; Mardekian, Stacey K.
• Other Names: Pambuccian Stefan Academic Editor.
• Is Part Of: Case reports in pathology. Volume 2018(2018)
• Publication Date: 2018-09-13
• Subjects: Pathology -- Periodicals; Pathology; Pathology; Electronic journals; Periodicals; Periodicals; Case Reports; Fulltext; Internet Resources; Periodicals; 616.07
• DOI: 10.1155/2018/8741017
• Languages: English
• ISSNs: 2090-6781

Abstract

Abstract : Sinonasal non-intestinal-type adenocarcinoma (non-ITAC) is a rare, morphologically diverse neoplasm of the head and neck. Squamoid morular metaplasia has recently been reported as an occasional finding in non-ITAC. Interestingly, these squamoid morules often show aberrant expression of CDX2 as well as nuclear expression of β -catenin, similar to other tumors that show this type of metaplasia, but the underlying mechanism responsible for this finding is not completely understood. We present two cases of low-grade non-ITAC with squamoid morules coexpressing CDX2 and nuclear β -catenin by immunohistochemistry, both of which were found to harbor a mutation in CTNNB1, the gene encoding β -catenin. This finding provides support that an alteration in the β -catenin pathway, including mutations in the β -catenin gene itself, is responsible for this recently described morphologic phenomenon in non-ITAC.