Dynamic Contrast-Enhanced Magnetic Resonance Imaging of Regional Nodal Metastasis in Nasopharyngeal Carcinoma: Correlation with Nodal Staging. (29th May 2017)

• Record Type: Journal Article
• Authors: Huang, Bingsheng; Kwong, Dora Lai-Wan; Lai, Vincent; Chan, Queenie; Whitcher, Brandon; Khong, Pek-Lan
• Other Names: Xu Ziyue Academic Editor.
• Is Part Of: Contrast media & molecular imaging. Volume 2017(2017)
• Publication Date: 2017-05-29
• Subjects: Diagnostic imaging -- Periodicals; Magnetic resonance imaging -- Periodicals; Contrast media (Diagnostic imaging) -- Periodicals; Contrast Media -- Periodicals; Diagnostic Imaging -- Periodicals; Substances de contraste -- Périodiques; Diagnostics moléculaires -- Périodiques; Imagerie médicale; Substance de contraste; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.0754
• DOI: 10.1155/2017/4519653
• Languages: English
• ISSNs: 1555-4309

Abstract

Abstract : Objective . To determine if the perfusion parameters by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) of regional nodal metastasis are helpful in characterizing nodal status and to understand the relationship with those of primary tumor of nasopharyngeal carcinoma (NPC). Materials and Methods . Newly diagnosed patients imaged between August 2010 and January 2014 and who were found to have enlarged retropharyngeal/cervical lymph nodes suggestive of nodal disease were recruited. DCE-MRI was performed. Three quantitative parameters, K t r a n s, v e, and k e p, were calculated for the largest node in each patient. Kruskal-Wallis test was used to evaluate the difference in the parameters of the selected nodes of different N stages. Spearman's correlation was used to evaluate the relationship between the DCE-MRI parameters in nodes and in primary tumors. Results . Twenty-six patients (7 females; 25~67 years old) were enrolled. K t r a n s was significantly different among the patients of N stages (N1, n = 3 ; N2, n = 17 ; N3, n = 6 ), P = 0.015 . Median values (range) for N1, N2, and N3 were 0.24 min −1 (0.17~0.26 min −1 ), 0.29 min −1 (0.17~0.46 min −1 ), and 0.46 min −1 (0.29~0.70 min −1 ), respectively. There was no significant correlation between the parameters in nodes and primary tumors. Conclusion . DCE-MRI may play a distinct role in characterizing the metastatic cervical lymph nodes of NPC.