Application of exosomes for the alleviation of COVID‐19‐related pathologies. (1st June 2022)

• Record Type: Journal Article
• Authors: Rezabakhsh, Aysa; Mahdipour, Mahdi; Nourazarian, Alireza; Habibollahi, Paria; Sokullu, Emel; Avci, Çigir Biray; Rahbarghazi, Reza
• Is Part Of: Cell biochemistry and function. Volume 40:Number 5(2022)
• Page Start: 430
• Page End: 438
• Publication Date: 2022-06-01
• Subjects: COVID‐19 -- exosomes -- paracrine interaction -- regenerative potential -- stem cell -- therapeutic effects; Cytochemistry -- Periodicals; Cell metabolism -- Periodicals; Biochemistry -- Periodicals; Cytology -- Periodicals; 572
• DOI: 10.1002/cbf.3720
• Languages: English
• ISSNs: 0263-6484

Abstract

Abstract: The pandemic of COVID‐19 caused worldwide concern. Due to the lack of appropriate medications and the inefficiency of commercially available vaccines, lots of efforts are being made to develop de novo therapeutic modalities. Besides this, the possibility of several genetic mutations in the viral genome has led to the generation of resistant strains such as Omicron against neutralizing antibodies and vaccines, leading to worsening public health status. Exosomes (Exo), nanosized vesicles, possess several therapeutic properties that participate in intercellular communication. The discovery and application of Exo in regenerative medicine have paved the way for the alleviation of several pathologies. These nanosized particles act as natural bioshuttles and transfer several biomolecules and anti‐inflammatory cytokines. To date, several approaches are available for the administration of Exo into the targeted site inside the body, although the establishment of standard administration routes remains unclear. As severe acute respiratory syndrome coronavirus 2 primarily affects the respiratory system, we here tried to highlight the transplantation of Exo in the alleviation of COVID‐19 pathologies. Significance statement: Exosomes (Exo) are nanosized vesicles that are released from each cell type and can transfer therapeutic molecules to the injured sites. It has been shown that Exo therapy circumvents difficulties that are associated with whole cell‐based therapies. Due to recent advances in the field of Exo‐based therapies, the current review article highlighted recent data and the applicability of Exo during viral diseases such as COVID‐19. The mechanism action and superiority of Exo were also debated in detail.