Fetal and neonatal brain injury in twins complicated by twin anemia polycythemia sequence. (28th June 2022)

• Record Type: Journal Article
• Authors: Rosen, Hadar; Silber, Ronit; Schwartz, Anat; Avnet, Hagai; Lipitz, Shlomo; Shrot, Shai; Hoffmann, Chen; Weisz, Boaz; Yinon, Yoav
• Is Part Of: Prenatal diagnosis. Volume 42:Number 8(2022)
• Page Start: 978
• Page End: 984
• Publication Date: 2022-06-28
• Subjects: Prenatal diagnosis -- Periodicals; Fetus -- Diseases -- Diagnosis -- Periodicals; Electronic journals; 618.32075
• DOI: 10.1002/pd.6194
• Languages: English
• ISSNs: 0197-3851

Abstract

Abstract: Objectives: To determine the rate of fetal and neonatal brain lesions and define risk factors for such lesions in pregnancies complicated by Twin Anemia Polycythemia Sequence (TAPS). Methods: A retrospective cohort study of monochorionic twin pregnancies which were diagnosed with TAPS in a single tertiary medical center between 2013 and 2021. Pregnancies were followed with fetal brain neurosonogram every 2 weeks and fetal brain MRI (magnetic resonance imaging) was performed when indicated at 28–32 weeks of gestation; post‐natal brain imaging included neonatal brain ultrasound. Pregnancies with pre‐ and post‐natal brain lesions were compared to those without such findings. Results: Overall, 23 monochorionic diamniotic pregnancies were diagnosed with TAPS over the study period resulting in perinatal survival of 91.3% (42/46). In 6/23 (26%) pregnancies and 7/46 (15.2%) fetuses pre‐ or post‐natal brain lesions were detected, of whom five were the polycythemic twins and two were the anemic twins. Brain findings included intra‐cerebral hemorrhage and ischemic lesions and were diagnosed prenatally in 6/7 (85.7%) cases. No risk factors for severe brain lesions were identified. Conclusions: TAPS may place the fetuses and neonates at increased risk for cerebral injuries. Incorporation of fetal brain imaging protocols may enhance precise prenatal diagnosis and allow for accurate parental counseling and post‐natal care. Key points: What is already known about this topic? It has previously been reported that the neonatal outcome of monochorionic twins affected by Twin Anemia Polycythemia Sequence (TAPS) is favorable and comparable to gestational age‐matched uncomplicated monochorionic twins, yet more recent data suggests long‐term neurodevelopment may be hindered in these cases. Literature regarding prenatal brain imaging in pregnancies complicated by TAPS, which may allow prenatal diagnosis and appropriate counseling, remains scarce. What are the novel findings of this work? This is the first study to report fetal and neonatal brain lesions in pregnancies complicated by TAPS detected by prenatal brain neurosonography, MRI and postnatal cranial ultrasound. Our findings highlight the importance of incorporation of neurosonogram and fetal brain MRI into routine surveillance of monochorionic pregnancies complicated by TAPS, in order to optimize patient counseling and estimation of prognosis, whilst helping guide further management.