Microbiota in Tumors: From Understanding to Application. Issue 21 (23rd May 2022)

• Record Type: Journal Article
• Authors: Xie, Yifan; Xie, Feng; Zhou, Xiaoxue; Zhang, Lei; Yang, Bing; Huang, Jun; Wang, Fangwei; Yan, Haiyan; Zeng, Linghui; Zhang, Long; Zhou, Fangfang
• Is Part Of: Advanced science. Volume 9:Issue 21(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-05-23
• Subjects: anti‐tumor therapy -- intratumor microbiota -- microbial community heterogeneity -- omics technology -- source of microbes -- tumorigenesis; Science -- Periodicals; 505
• DOI: 10.1002/advs.202200470
• Languages: English
• ISSNs: 2198-3844

Abstract

Abstract: Microbes with complex functions have been found to be a potential component in tumor microenvironments. Due to their low biomass and other obstacles, intratumor microbiota is poorly understood. Mucosal sites and normal adjacent tissues are important sources of intratumor microbiota, while hematogenous spread also leads to the invasion of microbes. Intratumor microbiota affects the progression of tumors through several mechanisms, such as DNA damage, activation of oncogenic pathways, induction of immunosuppression, and metabolization of drugs. Notably, in different types of tumors, the composition and abundance of intratumor microbiota are highly heterogeneous and may play different roles in the progression of tumors. Because of the concern in this field, several techniques such as omics and immunological methods have been used to study intratumor microbiota. Here, recent progress in this field is reviewed, including the potential sources of intratumor microbiota, their functions and related mechanisms, and their heterogeneity. Techniques that can be used to study intratumor microbiota are also discussed. Moreover, research is summarized into the development of strategies that can be used in antitumor treatment and prospects for possible future research in this field. Abstract : Intratumor microbiota is a hot spot in tumor research. In recent years, remarkable progress has been achieved in functions and application potential of intratumor microbiota. This review summarizes source, mechanisms, heterogeneity, and research techniques of intratumor microbiota, and discusses their potential for clinical translation to provide new insights into cancer treatment.