Adiponectin, Retinoic Acid Receptor Responder 2, and Peroxisome Proliferator-Activated Receptor-γ Coativator-1 Genes and the Risk for Obesity. (29th August 2017)

• Record Type: Journal Article
• Authors: Fonseca, Ana Carolina Proença da; Ochioni, Alan Cleveland; Martins, Raisa da Silva; Zembrzuski, Verônica Marques; Campos Junior, Mario; Ramos, Vivianne Galante; Carneiro, João Regis Ivar; Nogueira Neto, José Firmino; Cabello, Pedro Hernan; Cabello, Giselda Maria Kalil
• Other Names: Harangi Mariann Academic Editor.
• Is Part Of: Disease markers. Volume 2017(2017)
• Publication Date: 2017-08-29
• Subjects: Diagnosis -- Periodicals; Biochemical markers -- Periodicals; Pathology -- Periodicals; 616
• DOI: 10.1155/2017/5289120
• Languages: English
• ISSNs: 0278-0240

Abstract

Abstract : Obesity is the most common nutritional disorder. This disease is a multifactorial disease influenced by environmental and genetic factors. This study investigated the relationship between common variants of adiponectin ( ADIPOQ ), retinoic acid receptor responder 2 ( RARRES2 ), and peroxisome proliferator-activated receptor- γ coativator-1 ( PPARGC1 ) and obesity-related traits and susceptibility. A total of 167 individuals with obesity and 165 normal-weight subjects were recruited. Genotype frequencies of rs182052 in ADIPOQ differed significantly between the groups. Genotype AA was observed at a higher frequency in case than in control subjects. Association analysis showed that the A allele was a risk factor for obesity. This polymorphism was associated with body weight, body mass index (BMI), and waist circumference. After stratification by BMI, eutrophic individuals with AA or AG genotypes had higher body weights and waist circumferences than those with GG genotypes. In the case group, no associations were observed, except for stratified subjects with morbid obesity that exhibited a progressive increase of body weight, BMI, and waist circumference when rs182052 A was present. No associations were observed between SNPs in RARRES2 and PPARGC1 and obesity or any other studied variables. The rs182052 polymorphism in ADIPOQ is associated with a higher risk for obesity and obesity-related parameters.