Richter's transformation as leptomeningeal infiltration in a chronic lymphocytic leukemia patient receiving venetoclax. Could blood‐brain barrier be a disease "sanctuary" during venetoclax treatment?. Issue 4 (4th March 2021)

• Record Type: Journal Article
• Authors: Dimou, Maria; Bitsani, Aikaterini; Roumelioti, Maria; Dimitrakopoulou, Aglaia; Iliakis, Theodore; Pardalis, Vasileios; Grafakos, Ioannis; Kalyva, Sotiria; Markopoulos, Athanasios; Kyrtsonis, Marie‐Christine; Panayiotidis, Panayiotis
• Is Part Of: Clinical case reports. Volume 9:Issue 4(2021)
• Page Start: 2249
• Page End: 2253
• Publication Date: 2021-03-04
• Subjects: blood‐brain barrier -- chronic lymphocytic leukemia -- leptomeningeal infiltration -- Richter's transformation -- venetoclax; Medicine -- Periodicals; 616.09
• DOI: 10.1002/ccr3.4002
• Languages: English
• ISSNs: 2050-0904

Abstract

Abstract: Our unique case of Richter's Transformation presenting as leptomeningial infiltration in a CLL patient receiving venetoclax raises questions on whether the drug penetrates the blood‐brain barrier and at what extend, especially in reduced doses given for drug‐drug interactions. Abstract : Our unique case of Richter's Transformation presenting as leptomeningial infiltration in a CLL patient receiving venetoclax raises questions on whether the drug penetrates the blood‐brain barrier and at what extend, especially in reduced doses given for drug‐drug interactions.