BRAF‐mutated malignant melanoma with chondrosarcomatous differentiation in inguinal nodal metastasis. Issue 4 (7th March 2021)

• Record Type: Journal Article
• Authors: Abbati, Francesca; Altimari, Annalisa; Corti, Barbara; Dika, Emi; Sperandi, Francesca; Melotti, Barbara
• Is Part Of: Clinical case reports. Volume 9:Issue 4(2021)
• Page Start: 2200
• Page End: 2204
• Publication Date: 2021-03-07
• Subjects: BRAF mutation -- chondrosarcomatous differentiation -- melanoma; Medicine -- Periodicals; 616.09
• DOI: 10.1002/ccr3.3982
• Languages: English
• ISSNs: 2050-0904

Abstract

Abstract: We report the case of a young woman who developed metastatic melanoma in the inguinal nodal region, which acquired chondrosarcomatous differentiation and preserved the BRAF mutation found in the primary tumor. The patient was treated with a BRAF/MEK inhibitor combination therapy (dabrafenib/trametinib), which was demonstrated to be effective and well‐tolerated. Abstract : BRAF‐mutated melanoma with chondrosarcomatoid differentiation and response to targeted therapy.